Neurological recovery
Perispinal Etanercept, the Tobinick protocol
Trained by the physician who invented it. Applied here since the protocol became available.
Perispinal Etanercept (PSE) is an off-label application of a well-established FDA-approved biologic, injected in a specific perispinal position and paired with a head-down maneuver that carries the medication into the central nervous system. It was pioneered by Dr. Edward Tobinick, MD. Dr. Cruz trained directly with Dr. Tobinick in clinic to learn the full protocol.
The research
What the published evidence actually shows
Published research led by Dr. Tobinick on more than 600 patients treated with Perispinal Etanercept reports roughly 80 percent neurological improvement across a wide range of cases, including patients treated 10 and even 20 years after the original stroke or brain injury. That time frame is the part most patients have never been told is possible.
The traditional teaching that stroke recovery closes after three to six months is not what this protocol, or our clinic experience, supports. We have treated patients decades out who regained motor function, speech, and cognitive clarity that every previous specialist had written off as permanent.
The lineage
Why training under the inventor matters
PSE is not a drug you simply inject. It is a protocol. Needle position, patient positioning, the head-down maneuver, and the timing of each step all determine whether the medication reaches the target tissue in the central nervous system.
Dr. Cruz spent time in clinic with Dr. Edward Tobinick, MD, the physician who developed PSE, learning the full protocol directly from the source. Kentuckiana Integrative Medicine is one of very few clinics in the country offering PSE with that direct training lineage.
For complex neurological presentations we pair PSE with our NEURO BRAIN Protocol, adipose-derived Messenger Signaling Cells combined with Photo-Energized PRP, delivered both perispinally and IV in the same visit.
Who we treat
Conditions PSE has been used for
Every neurological case we evaluate is different. We do not accept every referral. We do accept and treat a wide range of conditions, including chronic cases that have been told nothing more can be done.
- 01Stroke, both ischemic and hemorrhagic, including patients years post-event
- 02Traumatic Brain Injury (TBI) and CTE
- 03Parkinson's Disease
- 04Multiple Sclerosis
- 05ALS
- 06Long COVID neurological effects
- 07Post-stroke depression and foot drop
- 08Select cerebral palsy cases
The visit
What a PSE visit looks like in practice
A first PSE visit includes a full neurological evaluation, review of imaging and history, and the administration of the protocol under Dr. Cruz directly. The procedure itself is outpatient. Patients typically travel home the same day.
Response is tracked over the weeks and months that follow. Some patients notice changes in hours. Most see accumulating improvement over the next several weeks, with further gains when PSE is combined with the NEURO BRAIN Protocol.
Call (812) 913-4416 to see if you are a candidate. Bring imaging, a history of your stroke or injury, and your questions.
Begin
We treat what others have given up on.
Call for a consultation. Tell us what you've tried, what hasn't worked, and what a better year looks like. We'll tell you, plainly, whether we can help.
405 E. Court Ave., Ste 102, Jeffersonville, IN 47130 · Mon–Fri · 9 AM – 5 PM