Jeffersonville, IN · 5 min from Louisville, KY
When conventional medicine ends,
our work begins.
Dr. Rafael F. Cruz, MD has spent 30 years treating patients told nothing more could be done. Regenerative, neurological, and integrative medicine, across the bridge from downtown Louisville.
A second-opinion clinic
For patients with stroke, Parkinson's, TBI, treatment-resistant depression, severe arthritis, and chronic conditions that haven't resolved with conventional care.
Why choose us
Four reasons patients travel to Kentuckiana.
Direct lineage
Trained by the inventor of Perispinal Etanercept.
Dr. Cruz spent time in clinic directly with Dr. Edward Tobinick, MD, the physician who pioneered the procedure. Published research on 600+ patients shows roughly 80% neurological improvement, even years after the original event.
See the PSE programPeer-reviewed
The TACT trial, 1,708 patients, JAMA 2013.
Our chelation protocols are grounded in the Harvard-led NIH-funded trial showing a 41% cardiovascular event reduction in diabetics. This is evidence-based adjunctive cardiology.
Read the chelation programDecade of data
8+ years of IV ketamine, zero serious adverse events.
Internal tracking of our proprietary 5R Protocol consistently reports 75 to 85% response, compared with 35 to 48% for standard antidepressants.
See the Ketamine InstituteConcierge medicine
Patients travel from across the US, Canada, and Europe.
Families plan week-long stays around complex cases. Karen coordinates every detail from Louisville airport transport to hotel partnerships near the clinic.
For international patientsOur care
Three decades of
procedure, not prescription.
Dr. Cruz started in emergency medicine, trained in anesthesia and pain procedures, and has spent 20 years building an integrative practice. The hands are procedural, the mindset is root cause.
FlagshipNeurological recovery
Perispinal Etanercept & Neuro Brain Protocol
For stroke, TBI, Parkinson's, even years after the event.
Dr. Cruz was trained directly by Dr. Edward Tobinick, MD, the physician who pioneered Perispinal Etanercept. Published research on 600+ patients shows roughly 80% neurological improvement, with measurable recovery decades after the original injury.
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FlagshipMental health
The Kentuckiana Ketamine Institute
10+ years of IV ketamine. 5R Protocol. Zero serious adverse events.
For treatment-resistant depression, PTSD, OCD, bipolar, and chronic pain. Our proprietary 5R Protocol layers IV ketamine with amino acids, NAD+, magnesium, and targeted nutrition, reported response rates of 80–90% vs. 65–75% for standard ketamine and 36% for single antidepressants.
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FlagshipRegenerative medicine
Prolotherapy, PRP & Messenger Signaling Cell
Rebuild tissue. Skip surgery. Stay active.
One of the earliest U.S. clinics providing cellular biologics (since 2010). Prolotherapy, Prolozone, Triple PRP, and personal stem cell therapy using the patient's own Bone Marrow Aspirate, all delivered with ultrasound and fluoroscopic guidance.
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Cardiovascular
IV Chelation & Plaquex
Heart disease, peripheral artery disease, and vascular support, rooted in the TACT trial.
Certified in IV Chelation. Our cardiovascular protocols are informed by the peer-reviewed TACT trial led by Harvard cardiologist Dr. Gervasio Lamas, MD. We treat patients with advanced heart disease, PAD, and brain vascular disease.
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Medical weight loss
HCG Lifestyle & Semaglutide Programs
Supervised weight loss, full lab panel, and a plan you can keep.
A physician-supervised program built around Dr. Cruz's proprietary HCG Lifestyle Plan, with Phentermine, Semaglutide, Lipotropic injections, and coaching. Men's and women's tracks. Roughly 90% of our patients reach their target weight and keep it off.
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Advanced wound care
Wound Care Medical Center
Heal non-healing wounds in months, not years.
FDA-approved regenerative products under 21 CFR 1271.10 for chronic and acute wounds. Medicare-covered. For the patient who has been in dressing changes for years without progress.
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Healthgrades Choice
Neurology · 2024
The physician
Thirty years of refusing there's nothing more we can do.
Rafael F. Cruz, MD earned his medical degree at Wright State University in 1993 and completed an Emergency Medicine residency at St. Vincent Mercy Medical Center in Toledo. In 2002 he added an Anesthesia and Pain Procedures fellowship at the University of Louisville.
That procedural foundation is the reason patients drive from Indiana, Ohio, Tennessee, and beyond. Dr. Cruz was trained directly by Dr. Edward Tobinick, MD, the physician who pioneered Perispinal Etanercept, and was one of the earliest physicians in the United States to administer cellular biologics, beginning in 2010.
He is a founding member of the American Academy of Ozone Therapy, a certified Independent Medical Examiner, and a Healthgrades Choice Provider in Neurology.
In their own words
Patients who were told nothing more could be done.
Real reviews, verbatim, from Yelp, Healthgrades, and WebMD, where Dr. Cruz averages 5.0 across 56 reviews.
“Four years ago I had the luxury of getting treated by Dr. Cruz for severe arthritis in my knee. MRI showed a 12mm spot of cartilage missing. After one stem cell injection and five PRPs, my post-MRI showed only mild softening, with no cartilage missing. I used to take 25 Aleves a year. I haven't taken one in four years.”
Bryan G.
Knee regeneration patient · Yelp · Nov 2019
“Getting diagnosis and treatments that healed my a-fib and palpitations, when other doctors were wanting me to go under the knife, is a blessing. To know that Dr. Cruz knew of successful alternatives gave me a journey of hope.”
Sol A. J.
Cardiovascular patient · Healthgrades · Sept 2020
“After a hospital stay and facing nine weeks of radiation for prostate cancer, I resolved to employ non-allopathic approaches. Dr. Cruz was only a half hour away. I've now gotten a clean bill of health from both the oncologist and urologist. I've never seen nicer clinical facilities either.”
Anonymous
Prostate cancer supportive patient · WebMD · July 2023
“Dr. Cruz is a great physician, willing to spend time with you and explain your pathology in great detail. His care is impeccable and unmatched. At 64 I can still play tennis, thanks to his care.”
Gloria Cruz, MD
Physician patient · WebMD · June 2023
“Great experience with Dr. Cruz and Richell and the team. Dr. Cruz has helped me deal with a number of complex issues related to heavy metals toxicity, anxiety, and hormonal deficiencies. I appreciate his approach as a functional and integrative physician looking for the root cause, rather than simply the medical establishment's typical name-it, blame-it, tame-it approach.”
Brian S.
Heavy metals + hormone patient · Yelp · July 2018
“Dr. Cruz asked several follow-up questions. He then patiently answered several questions in different ways so I could grasp the concepts and methods. Unlike the 20 allotted minutes with most doctors.”
Toyota Steve
New patient consult · Healthgrades · Sept 2021
Individual results vary. These quotes reflect specific patient experiences and do not represent medical outcomes for all patients.
Frequently asked
Straightforward answers to the questions we hear most.
Can't find yours? Call us at (812) 913-4416.
Yes. Rafael F. Cruz holds an MD from Wright State University Boonshoft School of Medicine, completed an Emergency Medicine residency at St. Vincent Mercy (Toledo), and an Anesthesia and Pain Procedures fellowship at the University of Louisville. He was board certified in Emergency Medicine from 1997–2017 and is currently a Board Certified Independent Medical Examiner (CIME).
Begin
We treat what others have given up on.
Call for a consultation. Tell us what you've tried, what hasn't worked, and what a better year looks like. We'll tell you, plainly, whether we can help.
405 E. Court Ave., Ste 102, Jeffersonville, IN 47130 · Mon–Fri · 9 AM – 5 PM